*Corresponding author:
Hechmi Toumi, Vice-Director Laboratory EA-I3MTO, University of Orléans, Vice-President of the Institute of Research, Treatment and Prevention of Osteoporosis, CHR d’OrléansReceived: June 07, 2018; Published: June 14, 2018
DOI: 10.26717/BJSTR.2018.05.001226
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Osteoarthritis is a degenerative disease of joints and leading cause of joint pain resulting from subchondral bone hypertrophy and inflammation. Although, many researches have been focused to overcome the articular cartilage, the latter has proven to be a very difficult tissue to repair defeating researchers, surgeons, and patients. Numerous surgical techniques have been developed to address focal cartilage defects. One area that seems encouraging is cell-based therapies based on stem cells to promote cartilage repair. Several human body tissues contain mesenchymal stem cells from where these can be harvested and cultured. This review summarises autologous chondrocytes implantation, first generation, second generation, third generation and recent clinical trials on mesenchymal stem cells implantation.
Keywords: Osteoarthritis; Cartilage; Chondrocytes Implantation; Mesenchymal Stem Cells