*Corresponding author:
Yanqin Lu, Key Laboratory for Biotech-Drugs Ministry of Health, Key Laboratory for Rare & Uncommon Diseases of Shandong Province, Shandong Medicinal Biotechnology Centre, Shandong Academy of Medical Sciences, ChinaReceived: September 28, 2018; Published: October 04, 2018
DOI: 10.26717/BJSTR.2018.09.001824
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Wnts are secreted lipid-modified glycoproteins in most mammalian genomes. Wnt ligands are the essential components of Wnt signaling pathways. Before binding to specific receptors, Wnt proteins experienced post-translational modification of acylation and N-glycosylation mediated by acyltransferase porcupine. Mature Wnts are transported from the Golgi to plasma membrane under association with Wntless. Retromer complex, P24 and other molecules are all involved in the secretion and release of Wnts. In this review, we provide an update of the post-translational modification, secretion and release of Wnts.
Keywords: Wnts; Acylation; N glycosylation; Wntless; Retromer