The Association of Carotid Intima-Media Thickness with Endocrine Disrupting Chemicals

Wei Jie Wang^1,2, Chien Yu Lin^3,4, Ta Chen Su^5,6, Sheng Wen Ko¹ and Jui Hsiang Lin*^1,7,8

Received: December 05, 2018;   Published: December 14, 2018

DOI: 10.26717/BJSTR.2018.12.002207

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Abstract

Endocrine disrupting chemicals (EDCs) involving phthalate metabolites, Bisphenol A, and perfluorooctane sulfate are chemicals that have the capacity to modulate endocrine systems. EDCs may aggravate subclinical atherosclerosis in a population of adolescents and young adults. We review articles including environmental exposure of EDCs and carotid intima-media thickness to infer atherosclerotic potentials of EDCs exposure. Urinary metabolite of mono-2-ethylhexyl phthalate is the major component of phthalate-induced atherogenic pathogenesis. EDCs may aggravate subclinical atherosclerosis in the population of adolescents and young adults. The important circumstantial relationship between EDCs and subclinical atherosclerosis should pay more attention in primary prevention of environmental cardiology.

Keywords :Endocrine Disrupting Chemicals; Carotid Intima-Media Thickness; Atherosclerosis

Abbreviations : EDCs: Endocrine Disrupting Chemicals; DM: Diabetes Mellitus; MBzP: Mono-Benzyl Phthalate; MEHP: Mono-2-Ethylhexyl Phthalate; CIMT: Carotid Intima-Media Thickness; BPA: Bisphenol A; PFOA: Perfluorooctanoic Acid; PFOS: Perfluorooctane Sulfate; PFCs: Perfluorinated Compounds; NHANES: National Health and Nutrition Examination Survey