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Research ArticleOpen Access

Formulation and Evaluation of Aciclovir Loaded Novel Gelfor Topical Application

Bhupendra Prajapati1*, Manan Panchal1 and Umang Varia2

DOI: 10.26717/BJSTR.2017.01.000184

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    • 1Department of Pharmaceutics, Ganpat University, India
    • 2Department of Pharmaceutics, Smt. S. M. Shah Pharmacy College, India

    *Corresponding author: Bhupendra Prajapati, Department of Pharmaceutics, S.K. Patel college of Pharmaceutical Education and Research, Ganpat University, Ganpat Vidyanagar Mehsana-Gozaria Highway, Mehsana-384012, Gujarat, India

Received: July 06, 2017;   Published: July 11, 2017

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Abstract

The main objective of this work was to examine the capacity of a nano emulsion formulation for topical application of Acyclovir. Various o/w Nano emulsion were prepared by using drop by drop addition method. By constructing pseudo phase ternary diagram Nano emulsion area was identified. The optimized formulation of Nanoemulsions were subjected to thermodynamic stability tests. After stability study, stable formulation were characterized for droplet size, polydispersity index and viscosity. Using Franz Diffusion cell and abdominal skin of rat, permeation of Acyclovir was determined. After 8 hours, Formulation NEG1 shows 90.98 % of drug permeation through the rat abdominal skin and the marketed cream shows 50.59 % of drug permeation. 50 % of the drug permeation through the skin was shows after the 3 hours which in formulation NEG1 shows the increase in permeation rat abdominal skin layers as compare the marketed cream was probably due to the mean size of internal phase droplets, which were significantly smaller in Nanoemulsions. Nanoemulsion is a novel and commercially feasible approach to improve the Topical delivery of Acyclovir and has potential to increasing the skin permeability, improving stability.

Keywords:Acyclovir; Topical delivery; Anti-viral effects; Spontaneous emulsification method

Introduction | Experimental | Characterization of Nanoemulsion | Result and Discussion| Conclusion| Acknowledgement| References | Figures | Tables|