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Mini ReviewOpen Access

Adverse Health Consequences of Dietary Advanced Glycation End Products (ages) and Inhibitory Effects of Natural Ingredients on Ages

Volume 1 - Issue 5

Zihao Wei and Qingrong Huang*

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    • Department of Food Science, Rutgers University, USA

    *Corresponding author: Qingrong Huang, Department of Food Science, Rutgers University, 65 Dudley Road, New Brunswick, New Jersey 08901, United States

Received: October 11, 2017;   Published: October 16, 2017

DOI: 10.26717/BJSTR.2017.01.000443

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Abstract

Dietary advanced glycation end products (AGEs) may result in various adverse health consequences, such as inflammation, cancer, liver diseases, obesity, cardiovascular diseases, diabetes, proteostatis impairment and memory decline. Natural ingredients may be a promising strategy to inhibit AGEs generation and ameliorate health risks of AGEs. The mechanisms involved in inhibition of AGEs with use of natural ingredients include antioxidant activity, reactive carbonyl trapping, and suppressing pathways of RAGE (receptor of advanced glycation end product), MAPK (mitogen-activated protein kinases) and NF-κB (nuclear factor-kappa B).This mini review summarizes the present understanding of the adverse impact of AGEs on health and the inhibitory effect of natural ingredients on AGEs.

Keywords: Maillard reaction; Dietary advanced glycation end products; Adverse health consequences; Inhibitor; Natural ingredients

Abbreviations: AGEs: Advanced Glycation End Products; NAFLD: Non-Alcoholic Fatty Liver Disease; CML: Carboxy Methyl Lysine; RAGE: Receptor of Advanced Glycation End Product; MAPK: Mitogen Activated Protein kinases; LSOPC: Lotus Seedpod Oligomeric Pro Cyanidins

Abstract| Introduction| References|