Case ReportOpen Access

Leucocyte-Rich and Platelet-Rich Fibrin(L-PRF) for the Treatment of Medication-Related Osteonecrosis of the Jaw (MRONJ) with Long Term Follow-up

Volume 2 - Issue 2

**Onur Şahin*, Toghrul Aliyev and Birkan Tatar**

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- Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, İzmir
*Corresponding author: Onur Sahin, Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, İzmir Katip Çelebi Universty, Izmir, Turkey

Received: January 27, 2018; Published: February 05, 2018

DOI: 10.26717/BJSTR.2018.02.000729

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Abstract

Bisphosphonates (BPs), antiresorptive and antiangiogenic drugs are used to prevent metastatic bone cancers and to treat osteoporosis and Paget’s disease. Besides BPs, due to the growing number of osteonecrosis cases associated with other antiresorptive and antiangiogenic therapies, American Association of Oral and Maxillofacial Surgeons (AAOMS) recommends changing the terminology of bisphosphonate related osteonecrosis of the jaws (BRONJ) and favors the term medication related osteonecrosis of the jaws (MRONJ) in 2014. The aim of this article was to report to case of a 79-year-old male with using oral ibandronate with osteonecrosis in the left retromolar area of the mandible. The therapeutic approach consisted of debridement of te osteonecrotic area and using leucocyte-rich and platelet-rich fibrin (L-PRF) for the treatment of medication-related osteonecrosis of the jaw (MRONJ).

Keywords: Antiresorptive therapy; Osteonecrosis of the jaw; Platelet-rich fibrin; Medication related osteonecrosis

Abbreviations: BPs: Bisphosphonates; AAOMS: American Association of Oral and Maxillofacial Surgeons; MRONJ: Medication Related Osteonecrosis of Jaw; BRONJ: Bisphosphonate-Related Osteonecrosis of Jaw; LLLT: Low Dose Laser Therapy; PRF: Platelet-Rich Fibrin