Research ArticleOpen Access

Frequency Distribution and Risk Factors of Helicobacter Pylori Infection in Patients with Gastric Problems in Mardan Pakistan

Volume 3 - Issue 1

Rimsha, Mehwish Nawaz, Sulaiman Shams, Asifullah Khan, Hammad Hassan, Mohibullah Shah, Sahib Gul Afridi*

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- Department of Biochemistry, Abdul Wali Khan University, Pakistan
*Corresponding author: Sahib Gul Afridi, Department of Biochemistry, Abdul Wali Khan University, Pakistan

Received: February 26, 2018; Published: March 08, 2018

DOI: 10.26717/BJSTR.2018.03.000834

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Abstract

Helicobacter pylori (H. pylori) are a common chronic infection that is responsible for causing several gastro duodenal diseases and accounts for 84.3% of Gastric Cancer. The proposed study aimed at finding frequency of H. pylori infection and its associated risk factors in patients with gastric problems from Mardan, Khyber Pukhtunkhwa Pakistan. We carried out a cross-sectional study that included 200 subjects of age groups 11-50 years who underwent screening method of Immune Chromatographic Technique (ICT) in major hospitals of Mandan city. Results showed that 94 (47%) subjects were found positive for H. pylori in which males were 63 (67%) and females were 31 (33%).

Based on multivariate analysis frequency rate of H. pylori was higher as 41 (43%) subjects each in age groups 11-20 years and 21-30 years followed by 10 (10.60%) with age group of 31-40 years and 2 (2.12%) with age group of 41-50 years. Irrespective of age groups frequency rate was high in 30 (31.19%) subjects infected withindigestion problem. Those subjects which were educated had higher frequency rate 68 (72.34%) as compared to illiterate 26(27.65%). Our study concluded that frequency of H. pyloriin Mardan was observed to be very high (47%) among the subjects with gastric problems as compared to the prevalence worldwide and there had been a striking increase in males, younger and educated subjects.

Keywords: Helicobacter pylori; Frequency; Immune Chromatographic Technique

Abbreviations: RUT: Rapid Urease Test; PCR: Polymerase Chain Reaction; FISH: Fluorescent In Situ Hybridization; UBT: Urea Breath Test; ICT: Immune Chromatographic Technique; MMC: Mardan Medical Complex