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Research ArticleOpen Access

Oxidative Damage of Carotid Arteries in Diabetic Patients

Volume 3 - Issue 3

Vasiliki Mamareli1, Orestis Tanis2, Maria Kyriakidou2, Ioannis Mamarelis*6, Jane Anastassopoulou3, Emmanouil Koutoulakis4 and Christoforos Kotoulas5

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    • 1Department of Internal Medicine, NIMTS Veterans Army Hospital of Athens, Greece
    • 2Department of Chemical Engineering, National Technical University of Athens, Greece
    • 3International Anticancer Research Institute, 1st km Kapandritiou-Kalamou Road, Greece, 19014
    • 4Department of Cardiology, 401 Army General Hospital of Athens
    • 5Department of Cardiac Surgery, General Hospital IASO, Greece
    • 6Department of Cardiology, NIMTS Veterans Army Hospital of Athens, Greece

    *Corresponding author: Ioannis Mamarelis, Department of Cardiology, NIMTS Veterans Army Hospital of Athens, Greece

Received: March 12, 2018;   Published: March 29, 2018

DOI: 10.26717/BJSTR.2018.03.000901

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Abstract

In the present study, FT-IR spectra were used to study the carotid arteries of 20 diabetic patients. From the comparison of infrared spectra between insulin-dependent (type II) diabetic patients or diabetics on oral hypoglycemic drug treatment with the corresponding patient spectra having normal blood glucose levels, it was found that insulin-dependent(type II) diabetic patients showed more pronounced changes throughout the absorption spectrum range (4000-800 cm-1). Particularly, the observed increase of the intensities of the stretching vibration bands of ethylene (vCH2) groups indicated that the lipophilic environment of the membranes is significantly altered. This conclusion is attributed to the increase in the destructive effect of free radicals produced during oxidative stress in diabetics. Also from the shifts of the amide I and amide II absorption bands to lower frequencies it is concluded that the secondary structure of proteins has been changed from α-helix to β-sheet and random coil. The most significant changes were observed in the area where the C-O-C groups of sugars and C-O-P-O sugar-phosphate groups of DNA and phospholipids absorb as a result of the disease.

Keywords: Oxidative Damage; Atherosclerosis; Diabetes, Infrared Spectroscopy, SEM

Abstract| Introduction| Materials and Methods| Results and Discussion| Discussion| Conclusion| References|