Metabolomics Used in Herb-Induced Liver Injury

Geng Xingchao*², Wu Wenxiao^1,2, Wang Ting² and Li Bo²

Received: March 20, 2018;   Published: April 05, 2018

DOI: 10.26717/BJSTR.2018.03.000917

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Abstract

Metabolomics [1]. As a formidable tool, is usually used to systematically assess the molecular responses of living systems to all external stimuli, characterize pathological states, diagnostic information and mechanistic insights into biochemical effects of drugs, based on global metabolite profiles in biological samples [2]. Mass spectrometry (MS) and nuclear magnetic resonance (NMR) spectroscopy, two major analytical platforms, with visualization software, have driven forward the discipline of metabolomics. Traditional Chinese Medicine (TCM) with its focus on herbal use is popular and appreciated worldwide with increased tendency [3,4]. And treatment was perceived as fairly safe but discussions emerged more recently as to whether herb-induced liver injury (HILI) from herbal TCM is a major issue. The multi-component and multi-target nature of TCM makes toxicological research far more complex than that of chemical drugs. Looking for rapid and sensitive biological toxicity effect evaluation technology has become a major problem urgently to be solved in current TCM safety evaluation. Metabolomics can further be employed as a perfect approach to link the gap between TCM and molecular toxicology. We reviewed the applications of the metabolomics with two major analytical platforms for HILI researches.

Keywords: MS: Mass Spectrometry; TCM: Traditional Chinese Medicine; NMR: Nuclear Magnetic Resonance; HILI: Herb-Induced Liver Injury; AA: Aristolochic Acid

Introduction| NMR-Metabolomics Used in HILI| MS Metabolomics Used in HILI| Conclusion| References|