*Corresponding author:
Tomiyo Nakamura, Faculty of Agriculture, Ryukoku University, 1-5 Yokotani, Seta Oe-cho, Otsu, Shiga 520-2194, JapanReceived: April 09, 2018; Published: April 17, 2018
DOI: 10.26717/BJSTR.2018.03.000967
To view the Full Article Peer-reviewed Article PDF
Weight loss is frequent in patients with Alzheimer’s disease (AD), even in early disease stage [1]. Therefore, weight loss is a significant predictor of mortality in AD patients. The etiology of AD-associated weight loss is multifactorial, occurring when energy expenditure exceeds energy intake [2]. In addition, the loss of skeletal muscle protein, one of the causes of weight loss, occurs by an imbalance between the rate of protein synthesis and degradation [3]. Therefore, many studies have examined energy expenditure, energy intake, body composition, and other genetic factors in relation to weight loss in AD patients. This mini-review further discusses the factors leading to weight loss in AD patients.
Keywords: Alzheimer’s Disease; Weight Loss; Energy Expenditure; Energy Intake