*Corresponding author:
Hanumanthachar Joshi, Neuroresearch Laboratory, Department of Postgraduate studies and Research Sarada Vilas College of Pharmacy, KM Puram, Mysore-04, Karnataka, IndiaReceived: April 12, 2018; Published: April 27, 2018
DOI: 10.26717/BJSTR.2018.04.001010
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Background: Memory loss is a most disabling feature of cognitive disorders which disrupts the life styles of patients and equally affects the patient caregivers. Management and treatment of memory loss is highly challenging as no potential remedy is available at present for the complete cure. In this study, antiamnesic and neuroprotective efficacy of methanolic extract of dried leaves of Mimusops Elengi Linn. (MEE) was investigated in mice.
Methods: Elevated plus maze and Morris water maze were used for assessment of acquisition and retention. Scopolamine (0.4mg/kg, i.p.) and diazepam (1mg/kg, i.p.) induced amnesia were the exteroceptive models.
Results: MEE (100 and 20mg/kg, p.o.) significantly improved acquisition and retention in amnesic mice. MEE also exhibited reversal effects in aged mice (aging induced amnesia). MEE significantly increased acetyl cholinesterase inhibitory activity in the mouse brain. M. Elengi exhibited potential neuroprotective effects.
Conclusion: Metholic extract of M. Elengi can prove to be a potential cognition improving agent which can be beneficial in management of various cognitive disorders found in elderly.
Kewords: Acetyl Cholinesterase; Mimusops Elengi; Memory Loss; Scopolamine
Abstract| Introduction| Materials and Methods| Results| Discussion| Acknowledgement| References|