Effect of Papaverine on the Flow of Left Internal Thoracic (Mammary) Artery for Coronary Artery Bypass Grafting

Musfireh Siddiqeh*

Received: April 20, 2018;   Published: May 01,2018

DOI: 10.26717/BJSTR.2018.04.001022

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Abstract

Objective: To determine the effect of papaverine in the blood flow of internal mammary artery in patientsundergoing coronary artery bypass grafting surgery.

Study Design: Quasi-experimental study.

Place & Duration: Cardiac surgery departments of Punjab Institute of Cardiology in Lahore, Pakistan from 1stMarch 2015 to 1st November 2015.

Methods: This descriptive case series study enrolled 50 consecutive patients who had undergone elective coronary artery bypass grafting with cardiopulmonary bypass (CPB) with use of papaverine in internal mammary artery, aged range 36-78 years were selected from cardiac surgery departments of Punjab Institute of Cardiology, Lahore, Pakistan from 1stMarch 2015 to 30th November 2015. All patients were assessed pre-operatively and per-operatively blood flow of LIMA at baseline (before papaverine injection) for 15 seconds and after 30 minutes of intra-arterial papavarine injection is measured.

Results: Out of 50 patients of which 10(20%) were female while 40(80%) were male. The mean age of the patients was 54±11.79 years and the average number of graft was 2.6±0.72. Results showed significant improvement in mean blood flow of LIMA(12.81±8.07ml and 61.87±8.45ml per 15 seconds and one minute respectively at baseline while 27.23±11.54ml and 107.53±44.35ml per 15 seconds and one minute respectively after 30 minute of papaverine injection)as p-value ≤ 0.05.

Conclusion: Papaverineis safe and effective vasodilator for increasingmean blood flowof LIMA/LITA for coronary artery bypass grafting surgery.

Abbrevation: CPB: Cardiopulmonary Bypass; CAPG: Coronary Artery Bypass Grafting; LITA or LIMA: Left Internal Thoracic(Mammary) Artery; PDE III-I: Phosphodiesterase III inhibitor; LAD: Left Anterior Descending Artery; SD: Standard Deviation; SPSS: Statistical Package for Social Sciences; PAM: Mean Arterial Pressure

Abstract| Introduction| Material and Methods| Statistical Analysis| Results| Discussion| Conclusion| References|