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Research ArticleOpen Access

Periodontal Regeneration Using Gelatin Hydrogels Incorporating Basic Fibroblast Growth Factor

Volume 4 - Issue 2

Toshiyuki Tamura1, Shigetoshi Yokoya2, Yohei Kamata2, Yukihiko Kinoshita3, Yasuhiko Tabata4 and Goichi Matsumoto*3

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    • 1Department of Oral Interdisciplinary Medicine, Kanagawa Dental University, Japan
    • 2Department of Highly Advanced Clinical Stomatology, Kanagawa Dental University, Japan
    • 3Department of Oral and Maxillofacial Surgery, Kanazawa Medical University, Japan
    • 4Department of Biomaterials, Field of Tissue Engineering, Japan

    *Corresponding author:Goichi Matsumoto, Department of Oral and Maxillofacial Surgery, Kanazawa Medical University. 1-1 Daigaku, Uchinada, Kahoku-gunn, Ishikawa 920-0293, Japan

Received: April 23, 2018;   Published: May 02,2018

DOI: 10.26717/BJSTR.2018.04.001025

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Abstract

We report here the clinical effects of the sustained release of basic fibroblast growth factor (bFGF) from gelatin hydrogel in cases of periodontal disease with infrabony defects. Patients with moderate to advanced periodontitis were treated with a mucoperiosteal flap operation. At the time of surgery, each bone defect was filled with gelatin hydrogel incorporating bFGF (bFGF/gelatin hydrogel). Probing pocket depth (PPD), clinical attachment level (CAL), and radiographic bone level were evaluated before treatment and at 3, 6, and 12 months after treatment. There were significant improvements in clinical parameters after treatment. There were no adverse effects during the treatment period. Topical application of bFGF/gelatin hydrogel may promote periodontal regeneration in cases of chronic periodontitis with infrabony defects.

Keywords: BFGF; Gelatin Hydrogel; DDS; Regeneration; Infrabony Defects; Periodontitis; Clinical Trial

Abstract| Introduction| Material and Methods| Results| Discussion| Conclusion| References|