Research ArticleOpen Access

Evaluation of Colonoscopy Preparation Using Sodium Phosphate at Different Points in time - a Prospective,Randomized, Endoscopist-Blinded Study

Volume 4 - Issue 2

**Tao-Wei Ke¹, Yung Feng Huang³, William Tzu Liang Chen¹, Hong Chang Chen¹, Jau Jie You² and Yang Yuan Chen*³**

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- ¹Department of Colorectal Surgery, China Medical University Hospital, Taiwan
- ²Department of Colorectal Surgery, Changhua Christian Hospital, Taiwan
- ³Department of gastroenterology, Changhua Christian Hospital and Yuan-Lin branch, Changhua, Taiwan
*Corresponding author: Yang Yuan Chen, Department of gastroenterology, Changhua Christian Hospital, Taiwan

Received: April 24, 2018; Published: May 04,2018

DOI: 10.26717/BJSTR.2018.04.001030

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Abstract

Aim: To compare the quality of colonoscopy preparation in patients taking sodium phosphate solution for bowel cleansing at two different time points.

Patients and Methods: One hundred and thirty-three patients were randomized to receive sodium phosphate solution (Fleet®), either in the preceding evening or in the same morning of the colonoscopy. The endpoints of this study include colonic cleansing, determining tolerance and acceptability via a self-administered questionnaire, and assessment of the safety profile of the cleansing agent.

Results: The morning group provided superior results in the overall assessment. 90.8% of the morning group gave an overall assessment rating of “excellent” or “good” compared to 56.9% of the evening group (P<0.001). Generally, the morning group showed better results in stool amount, stool consistency, and bowel wall visualization. Higher rates of abdominal bloating and insomnia were seen in the evening group (53.9% vs 32.3%, P=0.021; 23.1% vs 7.7%, P=0.027). The morning group had significant increases in serum sodium and phosphate level as well as decrease in serum calcium level on the day following the colonoscopy without any clinical sequelae. Patient acceptability, vital signs, and body weights were comparable for both groups. 78.5% in the evening group and 81.5% in the morning group were willing to use the same preparation in the future. Preparation completion rates were high with no significant difference between the two groups (95.4% subjects in the evening group completed the preparation and 89.2% in the morning group, P=0.416).

Conclusion: Taking the sodium phosphate solution on the same day of the colonoscopy produced far superior results with consistent cleanliness throughout the colon. Patients were safety and had the benefit of not having to endure some of the overnight discomforts.

Keywords: Angiolymphoid Hyperplasia with Eosinophilia; Kimura’s Disease; Scalp and Face Nodules