Gastric Calcifying Fibrous Tumor: A Clinicopathologic Analysis of 2 Cases

Wei Zhao* and Zhao Li Li

Received: December 04, 2018;   Published: December 14, 2018

DOI: 10.26717/BJSTR.2018.12.002210

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Abstract

Calcifying fibrous tumor (CFT) is a rare benign mesenchymal tumor which shows a predilection for soft tissue and the abdominal cavity. CFT usually affected children and young adults. To date only twenty cases of CFTS have been reported in the literature confined to the stomach. We presented here two cases of gastric CFTS. One patient was 55-year-old man and the other was 56-year-old woman. The two patients presents with slight upper abdominal pain and dyspepsia. The two tumors both originated in the gastric body and gastric endoscopy revealed polypoid submucosal masses, covered by an intact mucosa. Both of the patients accepted a wedge resection of the stomach. Histology was typical with uniformly hypocellular coarse collagen, lymphoplasmacytic infiltrates and psammomatous calcifications. Immunohistochemically, the tumor cells were positive for vimentin and negative for CD117, CD34, DOG-1, S100, smooth muscle actin, desmin and ALK1.The two patients with available follow-up had no evidence of recurrence at 19 and 24 months.

Keywords :Stomach; Calcifying Fibrous Tumor; Gastrointestinal Stromal Tumors

Abbreviations : CFT: Calcifying Fibrous Tumor; SMA: Smooth Muscle Actin; ALK: Anaplastic Lymphoma Kinase; GIST: Gastrointestinal Stromal Tumors; IMT: Inflammatory Myofibroblastic Tumor