*Corresponding author:
Alan Kleinman, Primary Care Physician and An Engineer, California, USAReceived: December 05, 2018; Published: December 17, 2018
DOI: 10.26717/BJSTR.2018.12.002219
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It is well understood that combination therapy suppresses the evolution of drug resistance. The number of drugs necessary to do this depends on many factors. This paper addresses the key factors in the context of a treatment protocol for malaria which still saw the emergence of resistance despite the use of combination therapy. This paper gives general guidance on the principles of determining the kind and number of selection pressures needed to suppress the evolution of drug resistance.
Keywords :Evolution; Drug Resistance; Suppression; Combination Therapy; Immune Competence; Susceptibility
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