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Biomedical Journal of Scientific & Technical Research

September, 2019, Volume 22, 2, pp 16589-16592

Mini Review

Mini Review

Moderate Red Wine Intake in Secondary Prevention for Patients with Cardiovascular Disease

Jean Pierre Rifler*1,2 Bernard Hudelot3 and Norbert Latruffe1

Author Affiliations

1INSERM UMR 866 - LBMN, France

2C.H. Montbard, France

3Domaine Montmain, France

Received: October 21, 2019 | Published: October 29, 2019

Corresponding author: Jean Pierre Rifler, INSERM UMR 866 - LBMN, University of Burgundy, 6, bd Gabriel, 21000 Dijon, C.H. Montbard,21500 Montbard, France

DOI: 10.26717/BJSTR.2019.22.003734

Introduction

The cardioprotective effect of moderate and regular wine consumption in primary prevention has been well documented. The goal of the present investigation was to explore the possible benefits of wine intake on secondary prevention in patients with cardiovascular disease (Figure 1) [1].

Figure 1.

Materials and Methods

Clinical Protocol

Two randomised groups of early post myocardial infarction patients were compared: one receiving daily 2 x 125 mL of red wine** (n=18), the other water (n=15).

Blood Parameters Measurement

Total cholesterol, LDL, HDL and antioxidant status (Figure 2).

Blood Anti-Oxidant Status

KRL test, based on the hemolysis induced by radical attack, allows to measure the overall blood antiradical resistance. Antioxidant defenses contribute to maintain the membrane integrity and function of cells subjected to a radical attack, up to hemolysis. The resistance of blood at the radical attack is expressed when 50% of blood cells are lysed (T1 / 2 minutes).

Figure 2.

Results

Anti-Oxidant Level

For wine drinkers the half hemolysis mean time is 84.74 +/- 3.82 at day 0; 87.06+/-5.50 at D14 (p<0.009). For the abstinent, the averages are 85.63 +/-6.31 at day 0 and 85.34 +/-5.41 at D14. The differences were significant only for the red wine group (Figure 3).

Evolution of Lipid Profile

Wine group had a significant LDL (p<0.02), total cholesterol (p<0.04) and triacylglycerol (p< 0.05) decrease in only 2 weeks. For the abstinent group, total cholesterol and LDL cholesterol increased but not significantly; compensated by a significant increase in HDL. The antioxidant power of serum did not increase, so the increase of LDL leads to an increase of oxidized LDL and consequently deposits of atherosclerotic plaque in the arteries (Figures 4 & 5).

Conclusion

These results suggest that the antiradical effect provided by the Mediterranean diet is only effective if the red wine is an integral part of the program. Lipidic profile is also benefically modified by this red wine diet.

The present investigation demonstrates the advantage of moderated wine intake on secondary prevention in patients with cardiovascular disease (Figure 6).

Figure 3.

Figure 4.

Figure 5.

Figure 6: **Red wine used in the study.

References

Mini Review

Moderate Red Wine Intake in Secondary Prevention for Patients with Cardiovascular Disease

Jean Pierre Rifler*1,2 Bernard Hudelot3 and Norbert Latruffe1

Author Affiliations

1INSERM UMR 866 - LBMN, France

2C.H. Montbard, France

3Domaine Montmain, France

Received: October 21, 2019 | Published: October 29, 2019

Corresponding author: Jean Pierre Rifler, INSERM UMR 866 - LBMN, University of Burgundy, 6, bd Gabriel, 21000 Dijon, C.H. Montbard,21500 Montbard, France

DOI: 10.26717/BJSTR.2019.22.003734

Abstract

The cardioprotective effect of moderate and regular wine consumption in primary prevention has been well documented. The goal of the present investigation was to explore the possible benefits of wine intake on secondary prevention in patients with cardiovascular disease (Figure 1) [1].